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Medicine<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a58.7\uff09\u96dc\u8a8c\u5c01\u9762\uff0c\u4e26\u7372\u5f97\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u300b\uff08<em>Journal of the American Medical Association<\/em>\uff0c<em>JAMA<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a63.1\uff09\u5168\u6587\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u55ae\u7d14\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4f7f\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u98a8\u96aa\u964d\u4f4e48%\uff0c\u6b7b\u4ea1\u98a8\u96aa\u964d\u4f4e37%\u3002\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5c0d\u6bd4\u55ae\u7d14\u5316\u7642\u5ef6\u9577\u4e8613.2\u500b\u6708\uff0c\u5f9e8.2\u500b\u6708\u63d0\u5347\u523021.4\u500b\u6708\u3002\u6b64\u5916\uff0c\u63a5\u53d7\u8a72\u806f\u5408\u7642\u6cd5\u6cbb\u7642\u7684\u60a3\u8005\u53ef\u7372\u5f97\u66f4\u9ad8\u7684\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\uff0c\u66f4\u9577\u7684\u6301\u7e8c\u7de9\u89e3\u6642\u9593\uff08DoR\uff09\u548c\u66f4\u9ad8\u7684\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\uff0c\u4e14\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u9577\u671f\u751f\u5b58\u96a8\u8a2a\u8cc7\u6599\u57282024\u5e74ASCO\u5e74\u6703\u5c55\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u6cbb\u7642\u7d445\u5e74\u751f\u5b58\u7387\u9054\u523052.0%\u3002<\/p>\n\n\n\n<p>\u57fa\u65bc\u8a72\u9805\u7814\u7a76\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u5206\u5225\u65bc2021\u5e74\u548c2023\u5e74\u7372\u5f97\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u548c\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u6279\u51c6\u7528\u65bc\u665a\u671f\u9f3b\u54bd\u764c\u7684\u6cbb\u7642\uff0c\u662f\u5168\u7403\u9996\u500b\u7372\u6279\u9f3b\u54bd\u764c\u6cbb\u7642\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08ICI\uff09\u85e5\u7269\uff0c\u4e5f\u662f\u7f8e\u570b\u9996\u500b\u4e14\u552f\u4e00\u7528\u65bc\u9f3b\u54bd\u764c\u6cbb\u7642\u7684\u85e5\u7269\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642NPC\u76f8\u95dc\u9069\u61c9\u75c7\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u540c\u6b65\u63a5\u53d7\u82f1\u570b\u85e5\u54c1\u548c\u4fdd\u5065\u54c1\u7ba1\u7406\u5c40\uff08MHRA\uff09\u3001\u6fb3\u5927\u5229\u4e9e\u85e5\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u3001\u65b0\u52a0\u5761\u885b\u751f\u79d1\u5b78\u5c40\uff08HSA\uff09\u4ee5\u53ca\u4e2d\u570b\u9999\u6e2f\u885b\u751f\u7f72\u85e5\u7269\u8fa6\u516c\u5ba4\uff08DO\uff09\u7b49\u570b\u5bb6\u548c\u5730\u5340\u76e3\u7ba1\u6a5f\u69cb\u7684\u5be9\u8a55\u3002<\/p>\n\n\n\n<p>JUPITER-06\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u591a\u4e2d\u5fc3\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff08NCT03829969\uff09\uff0c\u65e8\u5728\u8a55\u4f30\u8207\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u7d2b\u6749\u9187\/\u9806\u9251\uff08TP\uff09\u7528\u65bc\u665a\u671fESCC\u4e00\u7dda\u6cbb\u7642\u7684\u7642\u6548\u53ca\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u7d50\u679c\u9996\u6b21\u5728\u6b50\u6d32\u816b\u7624\u5167\u79d1\u5b78\u6703\u5e74\u6703\uff08ESMO 2021\uff09\u4e0a\u4ee5\u53e3\u982d\u5f59\u5831\u5f62\u5f0f\u5831\u544a\uff0c\u96a8\u5f8c\u5728\u570b\u969b\u9802\u5c16\u816b\u7624\u5b78\u96dc\u8a8c\u300a<em>Cancer Cell<\/em>\u300b\uff08\u5f71\u97ff\u56e0\u6578\uff1a48.8\uff09\u548c\u300a\u81e8\u5e8a\u816b\u7624\u5b78\u96dc\u8a8c\u300b\uff08<em>Journal of Clinical Oncology<\/em>\uff0c\u5f71\u97ff\u56e0\u6578\uff1a42.1\uff09\u767c\u8868\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u53ef\u4f7f\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u60a3\u8005\u7372\u5f97\u66f4\u512a\u7684PFS\u548cOS\uff0c\u5176\u4e2d\u4e2d\u4f4dOS\u5ef6\u95776\u500b\u6708\uff0c\u9054\u523017\u500b\u6708\uff0c\u4e26\u986f\u8457\u964d\u4f4e\u60a3\u8005\u7684\u75be\u75c5\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u905442%\uff0c\u986f\u8457\u6539\u5584\u751f\u5b58\u7372\u76ca\uff0c\u4e14\u7121\u8ad6PD-L1\u8868\u9054\u5982\u4f55\u5747\u53ef\u7372\u76ca\u3002<\/p>\n\n\n\n<p>\u57fa\u65bc\u8a72\u9805\u7814\u7a76\uff0c2022\u5e745\u6708\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u6cbb\u7642ESCC\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u5728\u4e2d\u570b\u7372\u6279\u3002\u76ee\u524d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u7528\u65bc\u4e00\u7dda\u6cbb\u7642ESCC\u7684\u4e0a\u5e02\u7533\u8acb\u6b63\u5728\u63a5\u53d7MHRA\u7684\u5be9\u8a55\u3002<\/p>\n\n\n\n<p><strong>JUPITER-02\u3001JUPITER-06\u4e3b\u8981\u7814\u7a76\u8005\u3001\u4e2d\u5c71\u5927\u5b78\u816b\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u83ef\u6559\u6388<\/strong>\u8868\u793a\uff1a\u201c\u9f3b\u54bd\u764c\u548c\u98df\u7ba1\u764c\u90fd\u5177\u6709\u4e9e\u6d32\u5340\u57df\u9ad8\u767c\u7684\u7279\u9ede\uff0c\u6b50\u7f8e\u570b\u5bb6\u5728\u6b64\u985e\u7624\u7a2e\u9818\u57df\u7684\u5275\u65b0\u7642\u6cd5\u958b\u767c\u65b9\u9762\u8f03\u70ba\u7de9\u6162\u3002JUPITER-02\u548cJUPITER-06\u7814\u7a76\u7684\u51fa\u8272\u7684\u7814\u7a76\u6210\u679c\u8b49\u660e\u4e86\u5728\u9f3b\u54bd\u764c\u548c\u98df\u7ba1\u764c\u9818\u57df\uff0c\u4e2d\u570b\u5b78\u8005\u7684\u8a3a\u7642\u80fd\u529b\u548c\u81e8\u5e8a\u79d1\u7814\u6c34\u6e96\u5df2\u7d93\u4f4d\u5217\u5168\u7403\u9818\u5148\uff0c\u671f\u5f85\u9019\u9805\u2018\u4e2d\u570b\u65b9\u6848\u2019\u80fd\u5920\u5207\u5be6\u6539\u8b8a\u570b\u969b\u4e0a\u7f79\u60a3\u9019\u5169\u985e\u7624\u7a2e\u4e14\u7f3a\u4e4f\u6709\u6548\u6cbb\u7642\u624b\u6bb5\u7684\u60a3\u8005\u5883\u9047\uff0c\u70ba\u4ed6\u5011\u5e36\u4f86\u66f4\u597d\u7684\u751f\u5b58\u5e0c\u671b\uff01\u201d<\/p>\n\n\n\n<p><strong>\u541b\u5be6\u751f\u7269\u7e3d\u7d93\u7406\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u9112\u5efa\u8ecd\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u2018\u7acb\u8db3\u4e2d\u570b\uff0c\u4f48\u5c40\u5168\u7403\u2019\u662f\u541b\u5be6\u751f\u7269\u5275\u7acb\u4e4b\u521d\u5373\u78ba\u7acb\u7684\u6230\u7565\u767c\u5c55\u76ee\u6a19\uff0c\u6b64\u6b21\u7279\u745e\u666e\u5229\u55ae\u6297\u7372\u5f97EC\u6279\u51c6\uff0c\u610f\u5473\u8457\u7e7c\u4e2d\u570b\u3001\u7f8e\u570b\u4e4b\u5f8c\uff0c\u6211\u5011\u5168\u7403\u5546\u696d\u5316\u4f48\u5c40\u7684\u8173\u6b65\u6b63\u5f0f\u9081\u5411\u6b50\u6d32\uff0c\u4e5f\u6a19\u8a8c\u8457\u6211\u5011\u5728\u5275\u65b0\u85e5\u7684\u7814\u767c\u548c\u751f\u7522\u54c1\u8cea\u518d\u6b21\u7372\u5f97\u570b\u969b\u6b0a\u5a01\u76e3\u7ba1\u6a5f\u69cb\u7684\u8a8d\u53ef\u3002\u672a\u4f86\uff0c\u6211\u5011\u5c07\u7e7c\u7e8c\u651c\u624b\u5408\u4f5c\u5925\u4f34\uff0c\u5168\u529b\u63a8\u52d5\u7279\u745e\u666e\u5229\u55ae\u6297\u5728\u6b50\u6d32\u5730\u5340\u7684\u5546\u696d\u5316\u843d\u5730\uff0c\u70ba\u66f4\u591a\u6d77\u5916\u60a3\u8005\u63d0\u4f9b\u4f86\u81ea\u4e2d\u570b\u7684\u9ad8\u54c1\u8cea\u5275\u65b0\u85e5\u7269\u3002\u201c<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><em>1. \u672c\u6750\u6599\u65e8\u5728\u50b3\u905e\u524d\u6cbf\u8cc7\u8a0a\uff0c\u7121\u610f\u5411\u60a8\u505a\u4efb\u4f55\u7522\u54c1\u7684\u63a8\u5ee3\uff0c\u4e0d\u4f5c\u70ba\u81e8\u5e8a\u7528\u85e5\u6307\u5c0e\u3002<\/em><\/h5>\n\n\n\n<h5 class=\"wp-block-heading\"><em>2. \u82e5\u60a8\u60f3\u77ad\u89e3\u5177\u9ad4\u75be\u75c5\u8a3a\u7642\u8cc7\u8a0a\uff0c\u8acb\u9075\u5f9e\u91ab\u7642\u885b\u751f\u5c08\u696d\u4eba\u58eb\u7684\u610f\u898b\u8207\u6307\u5c0e\u3002<\/em><\/h5>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u9f3b\u54bd\u764c<\/strong> <\/p>\n\n\n\n<p>\u9f3b\u54bd\u764c\u662f\u4e00\u7a2e\u767c\u751f\u65bc\u9f3b\u54bd\u90e8\u9ecf\u819c\u4e0a\u76ae\u7684\u60e1\u6027\u816b\u7624\uff0c\u662f\u5e38\u898b\u7684\u982d\u9838\u90e8\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u3002\u6839\u64daGLOBOCAN 2022\u767c\u4f48\u7684\u8cc7\u6599\u986f\u793a\uff0c2022\u5e74\u9f3b\u54bd\u764c\u5728\u5168\u7403\u7bc4\u570d\u5167\u78ba\u8a3a\u7684\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e12\u842c<sup>1<\/sup>\u3002\u7531\u65bc\u539f\u767c\u816b\u7624\u4f4d\u7f6e\u7684\u539f\u56e0\uff0c\u5f88\u5c11\u63a1\u7528\u624b\u8853\u6cbb\u7642\u3002\u65b0\u8fd1\u66f4\u65b0\u7684ESMO\u6307\u5357\u63a8\u85a6\u514d\u75ab\u6cbb\u7642\u806f\u5408\u5316\u7642\u7528\u65bc\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u9f3b\u54bd\u764c\u7684\u4e00\u7dda\u6cbb\u7642<sup>2<\/sup>\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">1.<a href=\"https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf\">https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf<\/a>.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">2.Bossi, P; Chan, AT; Even, C; Machiels, JP, et al.ESMO-EURACAN Clinical Practice Guideline update for nasopharyngeal carcinoma: adjuvant therapy and first-line treatment of recurrent\/metastatic disease. Ann Oncol, 2023; 34 (3): 247.<\/h6>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u95dc\u65bc\u98df\u7ba1\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u98df\u7ba1\u764c\u662f\u6d88\u5316\u9053\u9818\u57df\u6700\u5e38\u898b\u7684\u60e1\u6027\u816b\u7624\u4e4b\u4e00\u3002\u6839\u64daGLOBOCAN 2022\u767c\u4f48\u7684\u8cc7\u6599\u986f\u793a\uff0c\u98df\u7ba1\u764c\u662f2022\u5e74\u5168\u7403\u7b2c\u5341\u4e00\u5927\u5e38\u898b\u60e1\u6027\u816b\u7624\u548c\u7b2c\u4e03\u5927\u764c\u75c7\u6b7b\u4ea1\u539f\u56e0\uff0c\u65b0\u767c\u75c5\u4f8b\u6578\u8d85\u904e51.1\u842c\uff0c\u6b7b\u4ea1\u75c5\u4f8b\u6578\u8d85\u904e44.5\u842c<sup>1<\/sup>\u3002\u98df\u7ba1\u9c57\u764c\uff08ESCC\uff09\u548c\u817a\u764c\u662f\u98df\u7ba1\u764c\u7684\u5169\u7a2e\u4e3b\u8981\u7d44\u7e54\u5b78\u4e9e\u578b\u3002ESMO\u6307\u5357\u63a8\u85a6PD-1\u963b\u65b7\u6027\u6297\u9ad4\u806f\u5408\u5316\u7642\u7528\u65bcPD-L1\u8868\u9054\u967d\u6027\u7684\u665a\u671f\u6216\u8f49\u79fb\u6027ESCC\u7684\u4e00\u7dda\u6cbb\u7642<sup>2<\/sup>\u3002<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">\u3010\u53c3\u8003\u6587\u737b\u3011<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">1.https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/160-china-fact-sheet.pdf.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\">2.Obermannova R,Alsina M, Cervantes A,Leong T,Lordick F, Nilsson M,van Greeken NCT, Vogel A,Smyth EC; ESMO Guidelines Committee. ESMO Clinical Practice Guidline for diagnosis,treatment and follow-up.Ann Oncol.2022 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