{"id":4018,"date":"2026-07-21T21:09:00","date_gmt":"2026-07-21T13:09:00","guid":{"rendered":"https:\/\/www.junshipharma.com\/?p=4018"},"modified":"2026-07-29T15:51:01","modified_gmt":"2026-07-29T07:51:01","slug":"%e5%90%9b%e5%af%a6%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%96%ae%e6%8a%97%e8%81%af%e5%90%88%e5%8c%96%e7%99%82%e7%94%a8%e6%96%bc%e5%8f%af%e5%88%87%e9%99%a4%e2%85%b1-%e2%85%b2%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/www.junshipharma.com\/zh-hant\/%e5%90%9b%e5%af%a6%e7%94%9f%e7%89%a9%e7%89%b9%e7%91%9e%e6%99%ae%e5%88%a9%e5%96%ae%e6%8a%97%e8%81%af%e5%90%88%e5%8c%96%e7%99%82%e7%94%a8%e6%96%bc%e5%8f%af%e5%88%87%e9%99%a4%e2%85%b1-%e2%85%b2%e6%9c%9f\/","title":{"rendered":"\u541b\u5be6\u751f\u7269\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7528\u65bc\u53ef\u5207\u9664\u2161-\u2162\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u570d\u624b\u8853\u671f\u6cbb\u7642\u7684\u88dc\u5145\u7533\u8acb\u7372\u53d7\u7406"},"content":{"rendered":"\n

\u5317\u4eac\u6642\u95932026\u5e747\u670821\u65e5\uff0c\u541b\u5be6\u751f\u7269\uff081877.HK\uff0c688180.SH\uff09\u5ba3\u4f48\uff0c\u7531\u516c\u53f8\u81ea\u4e3b\u7814\u767c\u7684\u6297PD-1\u55ae\u6297\u85e5\u7269\u7279\u745e\u666e\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\u806f\u5408\u542b\u9251\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\uff0c\u7e7c\u4e4b\u672c\u54c1\u55ae\u85e5\u4f5c\u70ba\u8f14\u52a9\u6cbb\u7642\uff0c\u7528\u65bc\u53ef\u5207\u9664\u2161-\u2162\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u7684\u9069\u61c9\u75c7\u4fee\u8a02\u7684\u88dc\u5145\u7533\u8acb\u7372\u5f97\u53d7\u7406\uff0c\u672c\u6b21\u7533\u8acb\u9069\u61c9\u75c7\u7531\u7528\u65bc\u53ef\u5207\u9664\u2162A-\u2162B\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u6210\u5e74\u60a3\u8005\u64f4\u5c55\u70ba\u53ef\u5207\u9664\u2161-\u2162\u671f\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u7684\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n

\u80ba\u764c\u662f\u76ee\u524d\u5168\u7403\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u60e1\u6027\u816b\u76241<\/sup>\u3002\u64da\u7d71\u8a08\uff0c2024\u5e74\u4e2d\u570b\u80ba\u764c\u65b0\u767c\u75c5\u4f8b\u6578\u7d04\u70ba118\u842c\u4f8b\uff0c\u5360\u4e2d\u570b\u65b0\u767c\u764c\u75c7\u75c5\u4f8b\u6578\u768422.83%\uff0c\u4e2d\u570b\u80ba\u764c\u6b7b\u4ea1\u75c5\u4f8b\u6578\u7d04\u70ba74\u842c\u4f8b\uff0c\u5360\u4e2d\u570b\u764c\u75c7\u6b7b\u4ea1\u75c5\u4f8b\u6578\u768428.79%2<\/sup>\u3002NSCLC\u70ba\u80ba\u764c\u7684\u4e3b\u8981\u4e9e\u578b\uff0c\u7d04\u5360\u6240\u6709\u75c5\u4f8b\u768485%3<\/sup>\u3002\u5176\u4e2d\uff0c20-25%\u7684\u60a3\u8005\u521d\u8a3a\u53ef\u624b\u8853\u5207\u96644<\/sup>\uff0c\u4f46\u5373\u4fbf\u63a5\u53d7\u4e86\u6839\u6cbb\u6027\u624b\u8853\u6cbb\u7642\uff0c\u4ecd\u670930-55%\u7684\u60a3\u8005\u6703\u5728\u8853\u5f8c\u767c\u751f\u5fa9\u767c\u4e26\u6b7b\u4ea15,6<\/sup>\u3002\u6839\u6cbb\u6027\u624b\u8853\u806f\u5408\u5316\u7642\u662f\u9810\u9632\u75be\u75c5\u5fa9\u767c\u7684\u624b\u6bb5\u4e4b\u4e00\uff0c\u4f46\u5316\u7642\u4f5c\u70ba\u8853\u524d\u65b0\u8f14\u52a9\u6216\u8853\u5f8c\u8f14\u52a9\u6cbb\u7642\u7684\u81e8\u5e8a\u7372\u76ca\u6709\u9650\uff0c\u50c5\u80fd\u5c07\u60a3\u8005\u76845\u5e74\u751f\u5b58\u7387\u63d0\u9ad8\u7d045%7,8<\/sup>\u3002<\/p>\n\n\n\n

\u8fd1\u5e74\u4f86\uff0c\u4ee5PD-(L)1\u6291\u5236\u5291\u70ba\u4ee3\u8868\u7684\u514d\u75ab\u7642\u6cd5\u6b63\u5728\u6539\u8b8a\u816b\u7624\u6cbb\u7642\u683c\u5c40\u3002\u5176\u53ef\u901a\u904e\u89e3\u9664\u816b\u7624\u7d30\u80de\u5c0d\u514d\u75ab\u7d30\u80de\u7684\u514d\u75ab\u6291\u5236\uff0c\u91cd\u65b0\u555f\u52d5\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7d30\u80de\u4f86\u6bba\u50b7\u816b\u7624\uff0c\u9054\u5230\u9577\u671f\u63a7\u5236\u6216\u6d88\u9664\u816b\u7624\u7684\u6548\u679c\u3002PD-(L)1\u6291\u5236\u5291\u5df2\u88ab\u570b\u5167\u5916\u6b0a\u5a01\u80ba\u764c\u6cbb\u7642\u6307\u5357\u63a8\u85a6\u4f5c\u70ba\u53ef\u624b\u8853\u2161-\u2162\u671fNSCLC\u7684\u570d\u624b\u8853\u671f\u6a19\u6e96\u6cbb\u7642\u4e4b\u4e00\u3002<\/p>\n\n\n\n

\u672c\u6b21\u88dc\u5145\u7533\u8acb\u4e3b\u8981\u57fa\u65bcNEOTORCH\u7814\u7a76\uff08NCT04158440\uff09\uff0c\u8a72\u7814\u7a76\u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u6bd4\u8f03\u7279\u745e\u666e\u5229\u55ae\u6297\u6216\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u7528\u65bc\u2161\/\u2162\u671f\u53ef\u5207\u9664\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u570d\u624b\u8853\u671f\u6cbb\u7642\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u8a72\u7814\u7a76\u7531\u4e0a\u6d77\u4ea4\u901a\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u80f8\u79d1\u91ab\u9662\u9678\u821c\u6559\u6388<\/strong>\u64d4\u4efb\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u7814\u7a76\u5171\u8a08\u7d0d\u5165501\u4f8b\u2161-\u2162\u671f\u53ef\u5207\u9664\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u60a3\u8005\u3002\u4e3b\u8981\u7d42\u9ede\u70ba\u7814\u7a76\u8005\u8a55\u4f30\u7684\u2162\u671f\u53ca\u2161-\u2162\u671f\u60a3\u8005\u7684\u7121\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u3001\u76f2\u614b\u7368\u7acb\u4e2d\u5fc3\u75c5\u7406\uff08BIPR\uff09\u8a55\u4f30\u7684\u2162\u671f\u53ca\u2161-\u2162\u671f\u60a3\u8005\u7684\u4e3b\u8981\u75c5\u7406\u5b78\u7de9\u89e3\u7387\uff08MPR\u7387\uff09\u3002\u6b21\u8981\u7d42\u9ede\u5305\u62ec\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u3001\u7368\u7acb\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRC\uff09\u8a55\u4f30\u7684EFS\u3001\u5b8c\u5168\u75c5\u7406\u7de9\u89e3\u7387\uff08pCR\u7387\uff09\u3001\u7121\u75c5\u751f\u5b58\u671f\uff08DFS\uff09\u548c\u5b89\u5168\u6027\u7b49\u3002<\/p>\n\n\n\n

2023\u5e741\u6708\uff0cNEOTORCH\u7814\u7a76\u4e2d\u2162\u671f\u53ef\u5207\u9664NSCLC\u60a3\u8005\u7684EFS\u671f\u4e2d\u5206\u6790\u9054\u5230\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\uff0c\u65bc2023\u5e74\u7f8e\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\u5168\u9ad4\u5927\u6703\u7cfb\u52174\u6708\u6703\u8b70\u4ee5\u53caASCO\u5e74\u6703\u4e0a\u4ee5\u53e3\u982d\u5831\u544a\u5f62\u5f0f\u516c\u4f48\u4e86\u6700\u65b0\u7814\u7a76\u6210\u679c\uff0c\u4e26\u65bc2024\u5e741\u6708\u767b\u9802\u570b\u969b\u9802\u5c16\u6b0a\u5a01\u671f\u520a\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u300b\uff08Journal of the American Medical Association<\/em>\uff0c<\/em>JAMA<\/em>)9<\/sup>\uff0c\u70ba\u5168\u7403\u9996\u500b<\/strong>\u6297PD-1\u55ae\u6297\u7528\u65bcNSCLC\u570d\u624b\u8853\u671f\uff08\u6db5\u84cb\u65b0\u8f14\u52a9\u548c\u8f14\u52a9\u6cbb\u7642\uff09\u6cbb\u7642\u9054\u5230EFS\u967d\u6027\u7d50\u679c\u7684\u2162\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u806f\u5408\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\uff0c\u76f8\u8f03\u65bc\u570d\u624b\u8853\u671f\u55ae\u7d14\u5316\u7642\uff0c\u986f\u8457\u5ef6\u9577\u4e86EFS\uff08\u4e2d\u4f4dEFS\uff1a\u672a\u9054\u5230 vs. 15.1\u500b\u6708\uff0cP<0.001\uff09\uff0c\u964d\u4f4e\u75be\u75c5\u5fa9\u767c\u3001\u9032\u5c55\u6216\u6b7b\u4ea1\u98a8\u96aa\u905460%\uff08HR=0.40, 95% CI: 0.28-0.57\uff09\u3002\u540c\u6642\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7d44\u7684OS\u4e5f\u986f\u793a\u51fa\u660e\u986f\u7684\u7372\u76ca\u8da8\u52e2\uff08HR=0.62, 95% CI: 0.38-1.00\uff09\u3002\u6b64\u5916\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\u5c07pCR\u7387\u63d0\u5347\u81f3\u8fd125\u500d\uff08pCR\u7387\uff1a24.8% vs. 1.0%\uff09\uff0cMPR\u7387\u63d0\u5347\u81f3\u8fd16\u500d\uff08MPR\u7387\uff1a48.5% vs. 8.4%\uff09\u3002<\/p>\n\n\n\n

2023\u5e7412\u6708\uff0c\u57fa\u65bcNEOTORCH\u7814\u7a76\u7684\u671f\u4e2d\u5206\u6790\u7d50\u679c\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u542b\u9251\u5316\u7642\u570d\u624b\u8853\u671f\u6cbb\u7642\u53ef\u5207\u9664\u2162A-\u2162B\u671fNSCLC\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u7372\u5f97\u6279\u51c6\uff0c\u662f\u6211\u570b\u9996\u500b\u3001\u5168\u7403\u7b2c\u4e8c\u500b<\/strong>\u7372\u6279\u7684\u80ba\u764c\u570d\u624b\u8853\u671f\u7642\u6cd5\uff0c\u4e26\u5df2\u7d0d\u5165\u300a\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff082025\u5e74\uff09\u300b\u3002\u8a72\u7642\u6cd5\u4e5f\u7372\u5f97\u4e862024\u7248\u300aCSCO\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u8a3a\u7642\u6307\u5357\u300b\u6700\u9ad8\u7b49\u7d1a\u63a8\u85a6\u3002<\/p>\n\n\n\n

2026\u5e745\u6708\uff0cNEOTORCH\u7814\u7a76\u5b8c\u6210\u6700\u7d42\u5206\u6790\uff0c\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u2161-\u2162\u671f\u4eba\u7fa4\u7684EFS\u3001MPR\u7387\u4ee5\u53ca\u2162\u671f\u4eba\u7fa4MPR\u7387\u5747\u9054\u5230\u65b9\u6848\u9810\u8a2d\u7684\u512a\u6548\u754c\u503c\u3002<\/p>\n\n\n\n

2026\u5e747\u6708\uff0cNEOTORCH\u7814\u7a76\u4e2d\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7528\u65bc\u53ef\u5207\u9664NSCLC\u570d\u624b\u8853\u671f\u6cbb\u7642\u7684\u2162\u671f\u60a3\u8005\u7684\u624b\u8853\u7d50\u5c40\u4e8b\u5f8c\u5206\u6790\u7d50\u679c\uff0c\u5168\u6587\u6b63\u5f0f\u767c\u8868\u65bc\u5916\u79d1\u9818\u57df\u570b\u969b\u9802\u5c16\u671f\u520a\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u00b7\u5916\u79d1\u5b78\u300b\uff08JAMA Surgery<\/em>\uff0910<\/sup>\u3002\u672c\u6b21\u5206\u6790\u805a\u7126NEOTORCH\u7814\u7a76\u4e2d\u5b8c\u6210\u624b\u8853\u7684\u2162\u671fNSCLC\u60a3\u8005\uff0c\u7cfb\u7d71\u8a55\u4f30\u4e86\u570d\u624b\u8853\u671f\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u5c0d\u624b\u8853\u5be6\u65bd\u3001\u4f75\u767c\u75c7\u53ca\u751f\u5b58\u7b49\u7d50\u5c40\u7684\u5f71\u97ff\u3002\u7d50\u679c\u986f\u793a\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u986f\u8457\u964d\u4f4e\u624b\u8853\u53d6\u6d88\u7387\uff0817.8% vs. 26.7%\uff0cp=0.03\uff09\uff0c\u4f7f\u66f4\u591a\u60a3\u8005\u7372\u5f97\u4e86\u624b\u8853\u5207\u9664\u7684\u6a5f\u6703\uff0c\u4e14\u672a\u589e\u52a0\u570d\u624b\u8853\u671f\u98a8\u96aa\u548c\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002\u5728314\u4f8b\u5b8c\u6210\u624b\u8853\u7684\u60a3\u8005\u4e2d\uff0c\u8207\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u76f8\u6bd4\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u6709\u6548\u5be6\u73fe\u816b\u7624\u964d\u671f\u7387\u548c\u6dcb\u5df4\u7d50\u964d\u671f\u7387\u63d0\u5347\uff08\u816b\u7624\u964d\u671f\u7387\uff1a80.7% vs. 50.7%\uff0c\u6dcb\u5df4\u7d50\u964d\u671f\u7387\uff1a67.5% vs. 48.6%\uff09\uff0c\u6539\u5584\u4e86\u60a3\u8005EFS\u7372\u76ca\uff08HR=0.50\uff0c95% CI\uff1a0.33-0.74\uff1bp\uff1c0.001\uff09\u3002\u5728\u540c\u6a23\u5be6\u73fe\u816b\u7624\u964d\u671f\u6216\u6dcb\u5df4\u7d50\u964d\u671f\u7684\u60a3\u8005\u4e2d\uff0c\u7279\u745e\u666e\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u8f03\u5b89\u6170\u5291\u806f\u5408\u5316\u7642\u660e\u986f\u6539\u5584EFS\uff08HR\u5747\u70ba0.45\uff0cp=0.002\u548cp=0.009\uff09\u3002<\/p>\n\n\n\n

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\u3010\u53c3\u8003\u6587\u737b\u3011<\/h5>\n\n\n\n
1.https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/900-world-fact-sheet.pdf.
2.Rongshou Z, Kexin S, Bingfeng H, et al. Cancer incidence and mortality in China, 2024. J Natl Cancer Cent. 2026.
3.Planchard D, et al.. Ann Oncol 2018; 29 S4: iv192-iv237.\u202f
4.Liang Y, et al. Transl Lung Cancer Res 2013;2:403-10.
5.Uramoto H, et al. Transl Lung Cancer Res 2014;3:242-9.
6.Taylor MD, et al. Ann Thorac Surg 2012;93:1813-20.
7.Pignon JP, Tribodet H, Scagliotti GV, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group. J Clin Oncol. 2008;26(21):3552-3559.
8.Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data. Lancet. 2014;383(9928):1561-1571.
9.Lu S, et al. JAMA. 2024;331(3):201-211.
10.Fang W, Wang Y, Wang W, et al. Surgical Outcomes of Perioperative Toripalimab in Stage III Resectable Non\u2013Small Cell Lung Cancer: Post Hoc Analysis of the Neotorch Randomized Clinical Trial. JAMA Surg. Published online July 15, 2026.<\/h5>\n\n\n\n

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